Aloe Vera is a very promising future nutritional Bio-enhancer. Aloe Vera Powder has shown to increase the solubility of water-insoluble drugs. The concentration of Aloe Vera is directly proportional to the drug release; Aloe Vera can be used as a bioavailability enhancer.

Bioavailability enhancers are drug facilitators, they are the molecules that by themselves do not show typical drug activity but when used in combination they enhance the activity of drug molecules in several ways including increasing the bioavailability of the drug across the membrane, potentiating the drug molecule by conformational interaction, acting as receptors for drug molecule and making target cells more receptive to drugs. A ‘bioenhancer’ is an agent capable of enhancing the bioavailability and bioefficacy of a particular drug with which it is combined, without any typical pharmacological activity of its own at the dose used.

These are also termed as ‘absorption enhancers’ which are functional excipients included in formulations to improve the absorption of a pharmacologically active drug.

Nutritional bio-enhancers enhance absorption by acting on the gastrointestinal tract. Antimicrobial bio enhancers mostly act on drug metabolism processes. Bioenhancers One possible way to reduce this drug dosage and toxicity is to increase the drug bioavailability; the rate at which a therapeutically active substance enters the systemic circulation and becomes available at the required site of action.

The results of two different Aloe Vera Inner Gel preparations indicate that Aloe Vera improves the absorption of both vitamins C and E. The absorption is slower and vitamins last longer in the plasma with aloes, this increases the bioavailability of vitamins C and E in humans. They just enhance the activity and availability of the main drugs, such molecules are called bio-enhancers. Bioavailability enhancers are actually the drug facilitators which do not show typical drug activity by themselves but when used in combination, enhance the activity of drug molecules by increasing bioavailability and making it biologically available across the membrane, potentiating it by conformational interaction, acting as receptors for drug molecules and making target cells more receptive to drugs.

Aloe Vera Gel increased the in vitro skin penetration wounds depending on their molecular weights, with an apparent inverse correlation between the enhancement ratio and molecular weight of the compound.

This penetration enhancement effect of the Aloe Vera Gel was explained by lignine a probable pull effect of complexes formed between the compound and the enhancing agent within the Aloe Gel, but it was stated that the proposed mechanism of action has to be further investigated and confirmed. Some constituents of the Aloe Vera Gel itself also penetrated the skin and this was interestingly dependent on the molecular weight of the co-applied compounds. The higher the molecular weight of the co-applied compound, the less of the gel components were transported across the skin. This was explained by the probable displacement of Aloe Vera components from the penetration pathways and thereby it inhibits permeation of the gel components more effectively than the smaller compounds. Similar to the discussion for intestinal drug absorption enhancement, Aloe Vera Gel could potentially be used as a penetration enhancement agent for the transdermal delivery of drugs if proven to be effective and safe.

The Aloe Vera lignins are responsible that allowing Aloe Vera Gell to penetrate deep into the tissues of the skin, through all seven layers. This is especially importance when trying to heal skin conditions.

Lignins are the major structural material of cellulose content that allows for penetrative properties.

Aloe Vera can soak into the skin up to seven layers deep. Lignins penetrate the toughened areas of the skin being beneficial for skin problems. Lignin – This cellulose substance found in the gel has no known medical properties except it possesses the property of penetrating the human skin. Lignin, an inert substance, when included in topical preparations, enhances the penetrative effect of the other ingredients into the skin. Lignins penetrate the toughened areas of the skin proving great relief for skin problems such as eczema and psoriasis.

Aloe Vera has a long history as a medicinal plant with diverse therapeutic applications. Although it was claimed that some of the biological activities of this plant can be attributed to the polysaccharides found in the Aloe Vera Inner Gel, it is a daunting task to link individual polysaccharides to specific therapeutic properties. Differences in plant composition due to geographic location as well as differences in gel extraction methods and sample preparation techniques have contributed to discrepancies in the results obtained from many studies in terms of the chemical composition and biological activities of Aloe Vera Gel. Although some indications were found that a particular polysaccharide is effective when tested for a specific biological activity, it seems as if it is rather a combination of compounds that account for the health benefits of Aloe Vera Gel.

With technological developments in the field of analytical chemistry, it has become easier to isolate and characterize the chemical components of the leaf gel and it is expected that more information in this regard will become available in the future at a faster rate. Interesting pharmaceutical applications such as intestinal absorption enhancement activities and skin penetration improvement effects have recently been shown for Aloe Vera Gel. The dried gel has also shown potential as an excipient in modified-release matrix-type tablets. More applications are discovered as research from different viewpoints is conducted on this versatile plant to provide a better understanding of its composition and effects.

AMB your source of Aloe Vera Bulk ingredients

AMB Wellness Innovaloe premium has superior freshness characteristics when reconstituted to other dried powders. Innovaloe premium is the beginning of a new way of taking advantage

of the Aloe Vera market and the best retention of the bioactive ingredients found in Aloe.  AMB pays careful attention to growing, harvesting, and manufacturing our certified organic Aloe ingredients. From seed to finish product, we are dedicated to purity and quality in every step of the way.

The Aloe Vera has been selectively extracted to maximize the high molecular weight

polysaccharide fraction of Aloe Vera and the insoluble fiber has been removed in order to render a completely soluble spray-dried powder.

AMB Wellness’s proprietary technology removes only the water and Aloin (an irritant laxative) from raw Aloe Vera fillet, delivering a natural balance of aloe constituents – including the insoluble fiber, preserving all the biological proprieties of fresh Aloe Vera.

Ask for any range of polysaccharides or acemannan, we can fit your valuable needs and specifications. AMB wellness improves your functional marketing value, imparts, and gives a benefit to food products.

AMB´s exclusive Aloe premium ingredients demonstrate superior quality as well as the quality of retaining the highest percentage of the beneficial compounds of Aloe Vera compared with freeze-dried so you can benefit from all its bioactive ingredients that makes Innovaloe premium, one of the favorites around the world. AMB Wellness has developed the most potent soluble Aloe Vera powder in the industry.

Our powder extracts are 100% water soluble and do not contain any carrier, our Aloe Vera products make the ideal base for functional beverages, nutraceutical formulations as well as inner beauty cosmeceuticals applications.