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Acemannan
A key Polysaccharide from Aloe Vera
All you need to know about
Acemannan & Aloe Vera
How does Acetypol work?
Consumer perception's power is quite evident in the continually growing category of naturals; manufacturers need to be prepared to drive consumer interest into new options. The changing marketplace has triggered the development of a new natural application, and Aloe is the best ingredient for any natural product.
Aloe vera has enjoyed a long history of lay acceptance as possessing "curative" or "healing" qualities. Over the last few years, numerous books and articles meeting scientific standards have been written on Aloe vera. Organizations such as the Aloe Vera Council (IASC) and recognized medical institutions, through publications and case-histories of physicians, veterinarians, and other scientists, have given credence to the "aloe phenomenon".
The importance of chemicals found in aloes is indicated by the fact that they have been listed in every known pharmacopeia. Depending on how the leaves are processed, mucilage and sugars are the dehydrated gel's major components. Although conflicting reports have been observed, the mucilage is mainly composed of mannan or glucomannan.
A larger part of the gel is a mucilage of mainly polysaccharide nature with minor amounts of various other compounds. It has been observed that in some of the activities observed; there may be some synergistic action between the polysaccharide base and other components.
Polysaccharides present in the Aloe have a unique ability to adhere to the outer cell membranes, improving the natural permeability. In this way, Aloe enhances the supply of nutrients and oxygen to the cells and the transport of metabolic waste.
Aloe Enhancing Properties
Aloe Lignins are responsible for allowing Aloe Vera gel to penetrate deep into the skin tissues through all three layers. This is especially important when trying to heal skin conditions due to salicylic acid, and other anti prostaglandin compounds may be responsible for Aloe's local anti-inflammatory activity, possibly due to an inhibitory effect on the arachidonic acid pathway via cyclooxygenase. Lignin a cellulose-based substance. It has no known medicinal properties, but this is thought to enable the Aloe Vera, when applied topically, to penetrate through the human skin to the dermis layer where new skin cells are made. Lignins, a primary structural material of cellulose content that allows for penetrative properties. Aloe Vera can soak into the skin up to seven layers deep. Lignins penetrate the skin's toughened areas, being beneficial for skin problems such as eczema and psoriasis. This cellulose substance is found in the gel has no known medical properties except it possesses the property of penetrating the human skin. The salicylic acid components of Aloe make it a terrific anti-inflammatory and analgesic- pain reliever. The Phenolic compounds have a stimulating effect on the bowels and anti-biotic properties, aiding in gastric motility- softening stools. Lignins constitute a significant part of cellulose- an insoluble fibrous substance that is the main constituent of plant cell walls that allows for penetrative properties. It's these Lignins that enable Aloe Vera to soak into the skin up to three layers deep. Lignins penetrate the skin's toughened areas, proving great relief for skin problems such as eczema and psoriasis.
After Aloe Vera has penetrated well into the skin can be served with a moisturizer for a more significant benefit. It has been demonstrated that dry Aloe Vera extracts increase skin moisturization through a humectant mechanism. Indeed, this substance increases the quantity of water contained in the superficial part of the epidermis without increasing the TEWL (Trans Epidermal Water Loss), which is the loss of water that passes from inside a body through the epidermis (that is, either the epidermal layer of skin) to the surrounding atmosphere via diffusion and evaporation processes. Aloe Vera has calming effects, amino acids, and polysaccharides regenerators; it is the best to stimulate cell regeneration and moisturize the skin. Aloe Vera is also very suitable for preventing stretch marks' appearance (adolescence, pregnancy, diets...).
Conscious of this new trend AMB R&D department has flexible policies to support and develop products according to the specific needs of customers ' product formulations. Among its active components, the Aloe Vera extracts from AMB provides a high content of polysaccharides and more remarkable Acemannan content that can be incorporated into formulations for moisturizing, anti-inflammation, and skin lightening products, as well hair care products.
Due to the high demand for more specialized products, AMB Wellness has created ACETYPOL; our newest development aimed to offer beauty and skin moisturization to our customer's solution. This product is made through an exclusive technique, a proprietary process of AMB Wellness made from insulated polysaccharides present in the inner Aloe Vera Gel by micro filtering, retaining polysaccharides up to 50,000 Da. The final product has a polysaccharide content of 30-35% measured by HPLC/GPC, of which Acemmanan composes 60%.
Rapid development and understanding of our body's function mechanisms and chemistry have developed the need for new natural ingredients as Aloe Vera. The importance of Aloe Polysaccharides ingredients is vital for healthier skin. To preserve bioactive components of natural extracts, AMB Wellness ensures that functionalities of Aloe Vera will also be found in the final products.
ACETYPOL™ is perfect for formulations intended for high-end Cosmetics, health care, and nutraceuticals for its high efficacy. The nutraceutical and functional food industries endeavors to develop novel delivery systems, which require excipients that fulfill specific functions. The unique properties of ACETYPOL™ will improve your marketing value, imparting, and giving a benefit in any product application.
FEATURES OF ACETYPOL™
• A high concentration of acetylated polysaccharides
• Optimal distribution of molecular weight
• Excellent boost ingredient
"disclaimer" that FDA has not evaluated the claim. The disclaimer must also state that the dietary supplement product is not intended to "diagnose, treat, cure or prevent any disease," because only a drug can legally make such a claim.
Acemannan (the name often used for Aloe beta-glucomannans, acetylated polymannans, and mucopolysaccharides) is a long chain sugar that interjects itself into all cell membranes. This increases the membranes' fluidity and permeability, allowing toxins to flow out of the cell more easily and nutrients to enter the section more easily. This results in improved cellular metabolism throughout the body and an overall boost in energy production.
Acemannan, Poly Acetyl Mannose, or Poly Acetylated Mannans, "Acemannan is a purified drug comprised of a highly dispersed ß1,4-linked acetylated polymannan with an average molecular weight of 1 to 2 million Daltons." Acemannan, therefore, is a naturally occurring active ingredient of Aloe vera that can be isolated and purified into a drug. Acemannan consists of a polymer of β-1,4 linked mono-acetyl mannose as the main sugar present, with a broad range of molecular weights from the low thousands to the low millions found in the inner leaf parenchyma of Aloe Vera leaves. Acemannan is the immuno-modulator active ingredient of the Aloe Vera with an optimal molecular weight distribution; Acemannan is a long chain sugar that interjects itself into all cell membranes. This increases the membranes' fluidity and permeability, allowing toxins to flow out of the cell more easily and nutrients to enter the cell more easily.
Acemannan also acts as a potent anti-inflammatory agent. Protects the spinal cord from damage due to chemical poisons and harmful drugs. Detoxifies, cares, and stimulates the immune system's cells, improves metabolism, and provides increased energy levels. It is the natural bio-stimulant of the body.
Acemannan is stored in all cell membranes, and thus it achieves an immune-enhancing of whole our body against pathogenic parasites, bacteria, fungi, and viruses. Acemannan has shown several positive results as an aid in the treatment of immunodeficiency.
Glucomannan and acemannan have been proved to accelerate wound healing, activating macrophages, stimulating the immune system as well as anti-bacterial and anti-viral effects. Aloe Vera is anti-viral and anti-bacterial, Aloe not only provides vigorous overall immune system support but aids directly in the destruction of intravascular bacteria. The reason is Aloe's unique polysaccharide component.
The body's natural "complement system," a critical defense system involving a series of proteins, only needs to be activated to attack bacteria. The polysaccharides trigger these proteins in a sequence called the "cascade phenomenon" to take on a doughnut shape and insert themselves into the surface membranes of bacteria.
Technical Issues
Properties of Acemannan
Aloe barbadensis Miller is generally recognized as the "true aloe" because of its wide use and, reportedly, most effective healing power. Although in Japan, Aloe arborescens Miller traditionally has been used as a folk remedy for various ailments ranging from gastrointestinal disorders to athlete's foot. Aloe vera is a perennial plant with turgid green leaves joined at the stem in a rosette pattern. A mature plant's leaves may be more than 25 inches long with sawlike spikes along their margins.
Aloe vera contains two major liquid sources, a yellow latex (exudate) and a clear gel (mucilage). The dried exudate of Aloe barbadensis Miller leaves is referred to as Aloe Vera. The mucilaginous jelly from the parenchymal cells of the plant is referred to as Aloe vera gel. There are generally no anthraquinones to decompose and cause discoloration of the gel unless an improper processing technique contaminates it.
Freshly excised from the plant, Aloe vera gel has been used for centuries by those living where the plant naturally grows as a health and beauty aid.
Aloe vera gel is about 98.5% water by weight. More than 60% of the total solid is made up of polysaccharides of carbohydrate origin. Organic acids and inorganic compounds, especially calcium oxalate, account for the remainder of the solid residue. Whole leaves, exudates, and fresh gels of Aloe plants have been used for several human afflictions. Evidence of their use as a medicinal remedy can be traced to the Egyptians of 400 BC. Aloe vera was also used to embalm the dead and protect the embalmers from the death-causing agent. Other early civilizations used Aloe vera for skincare, to relieve insect stings and bites, to treat scratches and ulcerated skin, to promote wound healing, to prevent hair loss, and as a purgative. Aloe vera was used in the traditional medicine of many cultures as an anthelmintic, cathartic and stomachic and was used for leprosy, burns and allergic conditions. Depending on how the leaves are processed, mucilage and sugars are the major components of the dehydrated gel. The sugars found are galactose, glucose, mannose, rhamnose, xylose, and uronic acids. Although reports conflict, the mucilage is mainly composed of mannan or glucomannan.
For a long time, the controversy over the active substance(s) identity in Aloe vera was not settled. Therefore, it is essential to clearly distinguish between the components present in the gel and those found in the exudates. A majority of the gel is a mucilage of mainly polysaccharide nature with minor amounts of various other compounds. It has been observed that in some of the activities, there may be some synergistic action between the polysaccharide base and other components.
Literature which reports that polysaccharides possess pharmacological and physiological activities continues to flood the pages of well-respected scientific journals. It is, therefore, logical that the mucilaginous gel of the Aloe vera plant, which is essentially a polysaccharide, holds the secret to Aloe vera's medicinal properties. The controversy over whether the polysaccharide is a glucomannan, mannan, pectin, or other composition, is resolved by a series of chemical purification steps.
Chemical Properties of Acemannan
Acemannan is a fluffy, white, amorphous, slightly hygroscopic powder, which is poorly soluble in water and dimethyl sulfoxide and insoluble in most other organic solvents. This powder consists of linear b(1-4)-D-mannosyl units. The polysaccharide is a long chain polymer interspersed randomly with acetyl groups linked to the polymer through an oxygen atom. The generic name for the polymer is acemannan. The degree of acetylation is approximately 0.91 acetyl groups per monomer as determined by the alkaline hydroxamate method.
Pharmacological Properties of Acemannan
Aloe vera has enjoyed a long history of lay acceptance as possessing "curative" or "healing" qualities. Over the last few years, numerous books and articles meeting scientific standards have been written on Aloe vera. Organizations such as the International Aloe Vera Science Council and recognized medical institutions, through publications and case histories of physicians, veterinarians, and other scientists, have given credence to the "aloe phenomenon." Aloe vera has been featured extensively in the field of dermatology, especially for treating radiation-caused skin conditions. Mackee, X-rays, and Radium in the Treatment of Diseases of the Skin.
Several pharmacology studies have been conducted on Aloe vera gel in recent times.
Acemannan has also been shown to be a potent stimulator of the immune system. Acemannan induces Interleukin 1 (Ii-1) production and prostaglandin E2 (PGE2) in human peripheral blood adherent cells in culture. Acemannan is effective as an adjuvant and immune enhancer and can effectively treat cancer, viral disease, and infections. Because of the problems of bioavailability of conventional wound-healing agents, because of the relatively short in vivo half-life of most conventional wound-healing agents, because of the adverse immunological effects of most traditional wound-healing agents, because most traditional wound-healing agents may not conjugate to the proper carbohydrates, and because most wound-healing agents cannot be metabolized, the conventional way of treating a wound is to directly and locally apply the wound-healing agent within the wound site itself.
Despite the known therapeutic properties of many polysaccharides, there are few methods available to accelerate normal wound healing despite the availability of various gels for treating a wound or lesion. In humans' case, wound healing in healthy young adults is assumed to proceed at the maximum rate, and any intervention is confined to debridement, suturing, and infection control. Impaired wound healing is a significant problem in health care. Chronic, non-healing wounds are a significant cause of prolonged morbidity in the aged human population. This is especially the case in bedridden or diabetic patients who develop severe, non-healing skin ulcers. Thus decubitus ulcers, venous stasis ulcers, and diabetic foot ulcers present significant therapeutic problems to physicians and nurses in that they may fail to heal despite competent nursing care. In many of these cases, the delay in wound healing results from inadequate local blood supply due to continuous pressure or vascular blockage. As a result, much therapeutic intervention centers on restoring oxygenation to ischemic tissues.
This can include the use of occlusive dressings, the use of vascular grafts, or the use of hyperbaric oxygen. Wound care treatments are generally designed to change the wound's physical state by providing moisture or oxygenation, removing sources of pressure or irritation, or reducing the bacterial load. At present, there is no treatment directed toward modifying the actual wound healing process positively. Chronic, non-healing wounds in the aged and diabetic population is a wide-spread medical problem. Poor capillary circulation to peripheral tissues due to small artery atherosclerosis or venous stasis is usually based on the problem of failure to heal.
The tissues that are poorly perfused by blood are often infected with microorganisms that proliferate unchallenged by the body's innate defense systems that require oxygenated and nourished tissue to function.
In recent years, considerable effort has gone into studying cytokines and growth factors as molecules that may accelerate wound healing. Some of the most important of these cytokines are fibroblast growth factor, platelet-derived growth factor, and transforming growth factor. While these proteins have shown some success by topical application to decubitus ulcers, there is no evidence that they have a systemic effect. Indeed, given the short biological half-life of these compounds, they are unlikely to survive long when administered systemically. The possibility that they will have a systemic effect on wound healing is nil. They can also have serious adverse effects when administered systemically. Thus, there is a need to accelerate normal wound healing in a human by giving a wound-healing agent systemically, which causes wound repair and tissue regeneration.
